In vitro gametogenesis and genome editing

Scientists hope that the artificial generation of egg and sperm cells – so-called in vitro gametogenesis – can prevent the formation of mosaics in combination with genome editing methods since the changes are made at the very beginning of cell division in the germ cell. Furthermore, they hope to examine the cultivated precursor germ cells closely under laboratory conditions for any undesirable cell changes.

Further information:

Albrecht, S. / König, H. / Sauter, A. (2021): Genome Editing am Menschen. Endbericht zum Monitoring. TAB-Arbeitsbericht Nr. 191. Berlin: Büro für Technikfolgen-Abschätzung beim Deutschen Bundestag (TAB): 73. Online Version(German)

For an ethical controversy evaluating this link, see, e.g.:

Rueda, J. / Pugh, J. / Savulescu, J. (2022): The morally disruptive future of reprogenetic enhancement technologies. In: Trends Biotechnol. Online Version 

De Proost, M. / Segers, S. (2022): We need to talk about disruption in bioethics: a commentary on Rueda, Pugh and Savulescu. In: Trends Biotechnol. Online Version 

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