Immunological Tolerability of Research Cloning

The immune compatibility of SCNT and iPS cells in particular is the subject of current research, since it was previously assumed that, in contrast to hES cells, they do not cause rejection reactions. However, a study by Deuse et al., among others, also demonstrated an immune response in SCNT cells in the mouse model.

See for further information on the study in which the immune reaction of SNTC stem cells of mice was observed: 

Deuse, Tobias / Wang, Dong / Stubbendorff,  Mandy / Itagaki, Ryo / Grabosch, Antje / Greaves, Laura C. / Alawi, Malik / Grünewald, Anne / Hu, Xiaomeng / Hua, Xiaoqin / Velden, Joachim / Reichenspurner, Hermann / Robbins, Robert C. / Jaenisch, Rudolf / Weissman, Irving L. / Schrepfer, Sonja (2015): SCNT-Derived ESCs with Mismatched Mitochondria Trigger an Immune Response in Allogeneic Hosts. doi: 10.1016/j.stem.2014.11.003  Online Version

See for further information on the current state of research:

Fu, Xuemei / Li, Wenjuan / Liu, Xin / Xu, Yang (2017): The Immunogenicity and Immune Tolerance of Pluripotent STem Cell Derivatives. In: Frontiers in Immunology 8: no pag. doi: 10.3389/fimmu.2017.00645 Online Version 

Zhu, Wenliang / Li, Mengqi / Wu, Yihui / Hu, Baoyang (2018): Precise immune tolerance for hPSC derivatives in clinical application. In: Cellular Immunology 326, 15-23. doi: 10.1016/j.cellimm.2017.08.005 Online Version 

Deuse, Tobias / Hu, Xiaomeng / Agbor-Enoh, Sean / Koch, Martina / Spitzer, Matthew H. / Gravina, Alessia / Alawi, Malik / Marishta, Argit / Peters, Bjoern / Kosaloglu-Yalcin, Zeynep / Yang, Yanqin / Rajalingam, Raja / Wang, Dong / Nashan, Bjoern / Kiefmann, Rainer / Reichenspurner, Hermann / Valantine, Hannah / Weissman, Irving L. / Schrepfer, Sonja (2019): De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans. In: Nature Biotechnology 37, 1137-1144. doi: 10.1038/s41587-019-0227-7 Online Version

Gouveia, Chantel / Huyser, Carin / Egli, Dieter / Pepper, Michael S. (2020): Lessons Learned from Somatic Cell Nuclear Transfer. In: International Journal of Molecular Sciences 21 (7), 2314. doi: 10.3390/ijms21072314 Online Version 

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