Fabio Candotti and Marina Cavazzana et al. provide a deeper insight into possible therapeutic approaches for the treatment of immune defects by gene transfer in blood stem cells:

Candotti F. (2014). Gene transfer into hematopoietic stem cells as treatment for primary immunodeficiency diseases. International journal of hematology, 99(4), 383–392. https://doi.org/10.1007/s12185-014-1524-z

Touzot, F., Hacein-Bey-Abina, S., Fischer, A., & Cavazzana, M. (2014). Gene therapy for inherited immunodeficiency. Expert opinion on biological therapy, 14(6), 789–798. https://doi.org/10.1517/14712598.2014.895811